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Product details
File Size: 4716 KB
Print Length: 355 pages
Page Numbers Source ISBN: 1848313470
Publisher: Columbia University Press; 1 edition (March 6, 2012)
Publication Date: March 6, 2012
Sold by: Amazon Digital Services LLC
Language: English
ASIN: B0074MTTEK
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#178,919 Paid in Kindle Store (See Top 100 Paid in Kindle Store)
If you are looking for a comprehensive introduction to the science of epigentics, this will serve you well. It was a relatively easy and enjoyable read.The criticism of its intended audience being unclear is fair. At times, it seems to be aimed at a rather lay audience with slightly odd analogies that over simplify almost to a fault. A few pages later, jargon and technicalities are tossed around that definitely require a solid background in biology to follow with any ease. This has the discordant effect of making the simplistic analogies seem even more odd. It can’t seem to decide if it expects you to remember only basic high school biology or if it prefers you’ve had at least a couple of undergraduate level courses in molecular biology and genetics.That being said, it was incredibly helpful in updating my understanding of this field. As a biology major in the ‘90s, this field was so nascent that it was barely addressed, let alone studied thoroughly. As a teacher of AP Bio in high school today, I needed an update on vertebrate gene regulation in order to be able to competently address the topic in my classroom. This book provided exactly that. While I won’t be teaching most of the advanced details in this book, I will be adjusting a few critical things to ensure alignment with today’s knowledge.Even better, it reminded me why I have always found genetics so fascinating. It’s even more so now than it was 25 years ago. As so often happens in emerging fields, each intriguing answer leads to dozens more questions. If you think the way a basic prokaryotic operon works is pretty cool, learning about mammalian epigenetic gene regulation will make your brain geek out with intellectual joy.
This is my first book on Epigenetics and it’s fascinating how different situations, actions, or experiences in our lives can affect our cells. Events that happened to our parents, grandparents, and so forth can also affect our cells in ways science is just starting to understand. I liked how Nessa Carey laid out the book. She starts with a history and some examples of epigenetics. She then discusses cells and how they work and how epigenetics is contributing to understanding diseases such as cancer and Alzheimer’s. She looks at why identical twins are not truly identical at the cellular level and how psychological trauma at an early age can affect us. She finishes the book with what we can expect to see in the future from the field of Epigenetics.I learned a lot from this book and want to learn more about this topic. I did find it difficult to stay engaged, partly because of Carey’s abundant use of adverbs, and partly because I’m not well versed in biology. Maybe if I had a better basic understanding before going in – it’s been a long time since I took a college biology course – it would’ve been more engaging for me. Overall a great introduction to the field.
This is a fine introduction to the topic by an extremely knowledgeable researcher. Carey tries to make it all very accessible to the novice, but in fact it presupposes a fair amount of understanding of molecular biology, especially of how DNA and RNA work, and at least a rudimentary understanding of protein folding and heredity.I felt there was too great an emphasis on epigenetic causes of human diseases, about which fairly little is known (except for a few rare but well-explored cases). Therefore, I only skimmed the last few chapters.I read this book and also took a Coursera online course in epigenetics, but I still have no clear idea about the relationship between genetics and epigenetics as applied to inheritance patterns. I cannot imagine how to add epigenetic dynamics to the biological models I work with, or if they make any difference at all to population biology.
Very nicely written layman level intro to Epigenetics. Great analogies, good exposition, good emphasis about explaining why discoveries are important are unexpected. Read it as an informal textbook to an academic class in Epigenetics. Probably got 33% of all the learning from the book and 67% from the class, and I have a suspicion the the basic lessons of the book will stick more than the forest of class details about what protein acetylates what unit of the histone.Would possibly be nice to expose a little more of the molecular detail, without frightening horses and small children.
I have enjoyed the book, and I would definitely recommend it to novices and experts. I am a DNA methylation professional, I work on molecular mechanism of DNA methylation. I bought the book to have one place reference for the phenotypic aspects of epigenetics. I think that the author did an excellent job of balancing the text for different types of readers. The author gives the names of the researchers that did some key discoveries, so the interested reader can always go to google.scholar and pubmed for the original publications. The simple language, numerous comparisons and explanations makes this book readable to the people without expertise in epigenetics, but also to an average graduate with BSc degree.The book is not for people interested in molecular aspects of DNA methylation, but it does not need to be, since such text would not be for a wide audience. My only critique would be that the author should add few more figures, that could make the text bigger pleasure to read and browse. If there are about 10 more drawings in the text I would give it full five stars. I have no doubt that with rapid development of epigenetics, this book will come in newer editions. With few additional drawings, it will be a five star read. One missing figure could be changes in DNA methylation through embryonic development and gametogenesis. Congratulations to the author, Cheers to all readers.
I had to read excerpts from this book for a graduate level biology class. I was so interested in learning more about how epigenetics is changing our understanding of inheritance that I had to purchase it and read more. This should be required reading for all "older" biology teachers. Highly recommended!
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